张红双, 李杨亮, 陆佳. 急性前列腺炎患者血清前列腺特异性抗原的变化及其意义[J]. 蚌埠医学院学报, 2014, 38(5): 627-629.
    引用本文: 张红双, 李杨亮, 陆佳. 急性前列腺炎患者血清前列腺特异性抗原的变化及其意义[J]. 蚌埠医学院学报, 2014, 38(5): 627-629.
    Zhang Hongshuang, Li Yangliang, Lu Jia. Changes and significance of serum of acute prostatitis prostate specific antigen[J]. Journal of Bengbu Medical College, 2014, 38(5): 627-629.
    Citation: Zhang Hongshuang, Li Yangliang, Lu Jia. Changes and significance of serum of acute prostatitis prostate specific antigen[J]. Journal of Bengbu Medical College, 2014, 38(5): 627-629.

    急性前列腺炎患者血清前列腺特异性抗原的变化及其意义

    Changes and significance of serum of acute prostatitis prostate specific antigen

    • 摘要: 目的:观察急性前列腺炎患者血清总前列腺特异性抗原(T-PSA)、游离前列腺特异性抗原(F-PSA)、游离前列腺特异性抗原/总前列腺特异性抗原(F/T)比值的变化,探讨急性前列腺炎引起PSA升高的病理生理机制。方法:对34例急性前列腺炎患者分别于治疗前和治疗后1周、3个月检测T-PSA、F-PSA值,并计算F/T比值。结果:患者治疗后1周和治疗后3个月血清T-PSA和F-PSA均低于治疗前(P0.05~P0.01),治疗后3个月血清T-PSA亦低于治疗后1周(P0.05);治疗后3个月F/T比值高于治疗前(P0.05),治疗前和治疗后3个月与治疗后1周F/T比值差异均无统计学意义(P0.05)。治疗3个月后,7例患者PSA仍大于4 ng/ml,予行经尿道前列腺电切术或前列腺穿刺活检,其中1例为前列腺癌,其余均为前列腺结节性增生伴炎症细胞浸润。结论:急性前列腺炎会导致血清T-PSA、F-PSA显著升高,F/T比值降低;其机制是前列腺炎症形成过程中正常前列腺上皮血屏障的破坏及炎症充血期前列腺腺管上皮细胞增生分泌PSA增多。对PSA的动态观察对于前列腺炎与前列腺癌的鉴别意义重大。

       

      Abstract: Objective: To observe the of total prostate specific antigen in serum of patients with acute prostatitis (T-PSA), free prostate specific antigen (F-PSA), free prostate specific antigen / total prostate specific antigen (F/T) ratio, to explore the pathophysiological mechanism of acute prostatitis caused by increased PSA. Methods: in 34 cases of acute prostatitis patients respectively before treatment and 1 weeks after treatment, 3 months for detection of T-PSA, F-PSA value, F/T ratio was calculated. Results: Patients after 1 weeks and 3 months after treatment the serum T-PSA and F-PSA were lower than those before therapy (P0.05~P0.01), 3 months after treatment the serum T-PSA is less than 1 weeks after the treatment (P0.05); after 3 months of treatment F/T was higher than that before treatment (P0.05), before and after treatment the difference 1 weeks of F/T was 3 months and after treatment were not statistically significant (P0.05). After 3 months of treatment, 7 patients with PSA is greater than 4 ng/ml, treated by transurethral resection of the prostate or prostate biopsy, including 1 cases of prostate cancer, the rest are benign prostatic hyperplasia and inflammatory cell infiltration.Conclusions: acute prostatitis can lead to serum T-PSA, F-PSA were significantly increased, F/T decreased; the mechanism is prostatitis formation in normal prostate epithelial blood barrier damage and inflammatory hyperemia prostate gland proliferation of epithelial cells secrete more PSA. Dynamic observation of PSA for prostatitis and prostate cancer diagnosis and differential significance.

       

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