郭伟, 刘先富, 张明亮. 碳酸酐酶-Ⅸ在食管鳞状细胞癌组织中的表达及其临床意义[J]. 蚌埠医学院学报, 2014, 38(4): 453-455.
    引用本文: 郭伟, 刘先富, 张明亮. 碳酸酐酶-Ⅸ在食管鳞状细胞癌组织中的表达及其临床意义[J]. 蚌埠医学院学报, 2014, 38(4): 453-455.
    GUO Wei, LIU Xian-Fu, ZHANG Ming-Liang. Expression of carbonic anhydrase Ⅸ in esophageal squamous cell carcinoma and its clinical significance[J]. Journal of Bengbu Medical College, 2014, 38(4): 453-455.
    Citation: GUO Wei, LIU Xian-Fu, ZHANG Ming-Liang. Expression of carbonic anhydrase Ⅸ in esophageal squamous cell carcinoma and its clinical significance[J]. Journal of Bengbu Medical College, 2014, 38(4): 453-455.

    碳酸酐酶-Ⅸ在食管鳞状细胞癌组织中的表达及其临床意义

    Expression of carbonic anhydrase Ⅸ in esophageal squamous cell carcinoma and its clinical significance

    • 摘要: 目的:检测碳酸酐酶-Ⅸ(CAⅨ)在食管鳞状细胞癌组织中的表达,并探讨其与食管鳞状细胞癌临床病理参数的关系。方法:应用免疫组织化学法检测30例正常食管组织和68例食管鳞状细胞癌组织中CAⅨ的表达,分析其与食管鳞状细胞癌预后的关系。结果:CAⅨ在正常食管组织中的阳性率是6.67%,明显低于食管鳞状细胞癌组织中的72.06%(P0.01);CAⅨ的表达与食管鳞状细胞癌的临床分期、细胞分化程度和淋巴结转移均有一定关系(P0.05)。结论:CAⅨ在食管鳞状细胞癌中的高表达可能是判断食管鳞状细胞癌预后不良的指标之一。

       

      Abstract: Objective:To investigate the expression of carbonic anhydrase Ⅸ(CAⅨ) in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters.Methods:The expression of CAⅨ in 30 cases of normal esophageal tissues and 76 cases of esophageal squamous cell carcinoma tissues were detected by immunohistochemical staining,the relationships between CAⅨ expression and esophageal squamous cell carcinoma was evaluated.Results:The expression rate of CAⅨ in normal esophageal tissues(6.67%) was significantly lower than that in esophageal squamous cell carcinoma(72.06%)(P0.01).The expression of CAⅨ was significantly associated with the clinical stage,cell differentiation degree and lymph node metastasis of esophageal squamous cell carcinoma(P0.05).Conclusions:The high expression of CAⅨ is an important index in the estimation of esophageal squamous cell carcinoma prognosis.

       

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