Abstract: Objective:To study the diagnostic value of virtual touch quantification technology in liver fibrosis grades induced by chronic hepatisis B.Method:The study subjects were performed the measurements of liver shear wave velocity by using a ultrasonic instrument named ACUSON S2000,and were composed with 30 normal control and 96 patients with chronic hepatitis B.The cutoff values of shear wave velocity of different liver fibrosis stages were detected and the correlations between shear wave velocity and pathological grades of the liver were analyzed.Results:The results showed that except for the shear wave velocity values among the control group and liver fibrosis stage S0 and stage S1 groups,and between liver fibrosis stage S0 and stage S1 groups,there were significant differences about the shear wave velocity values between other groups(P0.01).Using the cutoff values of 1.38m/s,1.74 m/s,2.19 m/s and 2.53m/s for diagnosis of S1,S2,S3 and S=4,the corresponding areas under receiver operating characteristic were 0.808,0.8723,0.889 and 0.861 respectively,and the corresponding sensibilities were 75.8%,80.5%,79.2%,78.6%,the specificities were 77.3%,83.4%,84.1%,79.5% respectively.The significant positive correlations were found between the shear wave velocity values and the grade of fibrosis and inflammation(P＜0.05).Conclusions:Virtual tuoch quantification technology is a new non-invasive method to evaluate liver fibrosis grades induced by chronic hepatisis B.