Abstract: Objective:To explore the prophylactic effect of penehyelidine combined with tropisetron in prevention of nausea and vomiting after laparoscopic cholecystectomy.Methods:Sixty patients having received laparoscopic cholecystectomy were randomly divided into three groups:tropisetron combined with dexamethasone group(group A),tropisetron group(group B) and physiological saline group(group C),with 20 cases in each.The incidence of postoperative nausea and vomiting was observed within 24 hours after the operation.Results:The visual analogus scales(VAS) score of nausea at T1-T4 in group C was significantly higher than that in group A and group B(P0.01);the VAS score at T1 and T2 in group A was significantly lower than that in group B(P0.01);and there was no significant difference between the two groups in the VAS score at T3 and T4(P＞0.05).The incidence of vomiting after awakening from 0 to 6,0 to 12 and 0 to 24 hours in group A and group B was significantly lower than that in group C(P0.01);and the incidences of vomiting in group A and B had no statistically significant difference(P＞0.05).Conclusions:The application of penehydidine combined with tropisetron can obviously reduce the incidence of nausea and vomiting after laparoscopic cholecystectomy,and is more effective than using tropisetron alone.It is worth popularizing in clinical application.