Abstract: Eukaryotic cells by apoptosis in response to accumulation of unfolded proteins in the endoplasmic reticulum. At present, there is data to prove that the induced factors of endoplasmic reticulum stress and autophagy, recycling of macromolecules and organelles of eukaryotic cells, autophagy balance of endoplasmic reticulum stress induced endoplasmic reticulum expansion, promote cell survival.