Abstract: Objective: To observe the effect of sodium ferulate in treatment of chronic glomerulonephritis.Methods: Fifty-six cases of chronic glomerulonephritis were randomly divided into treatment group(30 cases) and control group(26 cases).The treatment group were administered sodium ferulate and the controls received guttae intravenously and vitamin B 6.The curative effect was evaluated after 21 days.Results: There was significant difference between the two groups in the time of symptom disappearing,the plasma contrast viscosity,24 h urine protein quantization and creatinine clearance rate(Ccr) and serum creatinine(Scr)(P<0.05 to P< 0.01).Conclusions: Sodium ferulate can improve the blood hypercoagulation state; reduce the content of urine protein,lower the blood pressure and minimize the injury of vascular endothelium.It may protect the renal function to a certain extent and improve the prognosis of chronic glomerulonephritis.