Abstract: Objective:To investigate the human papilloma virus(HPV) infection,and analyze the infection and distribution of 23 HPV subtypes in Fuyang area.Methods:The pathological diagnosis in 2 140 HPV detection women were implemented,the HPV subtype was analyzed using the flow-through hybridization and gene-chip.Results:The total infection,single infection and high-risk infection rates of HPV were 28.8%,58.3% and 22.9%,respectively.The most common types of HPV infections were in turn HPV16(21.4%),HPV 58(9.5%),HPV 52(7.3%),HPV 31(6.0%) and HPV 18(5.8%).The difference of the infection rates between high-risk type and each HPV subtype was not statistically significant(P>0.05).Conclusions:HPV16,52 and 58 types are the main infection type of HPV,the distribution of HPV subtype has regional specificity in Fuyang area.