Abstract: Objective: To investigate the clinical application value of serum procalcitionin(PCT) and prealbumin(PA) level in patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods: The changes of serum PCT,PA and white blood cell(WBC) levels,blood gas analysis and sputum culture of 72 patients with AECOPD before and after treatment were detected and compared.Results: There was no statistical differences of serum PCT and PA levels before treatment between sputum culture positive and negative groups(P>0.05),white blood cell count didn't change before and after treatment(P>0.05),however,there had statistical differences of serum PCT and PA levels before and after treatment(P<0.01).Conclusions: The changes of serum PCT and PA levels in AECOPD patients were more obvious,which were good diagnostic indicators.Combined with PCT and PA had more important reference value for AECOPD bacterial infection diagnosis and disease monitoring.