Abstract: Objective: To explore the analgesic effects and side effect of intravenous postoperative anlgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride. Methods: Forty cases undergoing orthopedic surgery of lower limb were randomly divided into two groups with twenty cases each:flurbiprofen axeyil injection 100 mg + tramadol hydrochloride 1 000 mg + ondansetron hydrochloride 8 mg (A group),tramadol hydrochloride 1 200 mg + ondansetron hydrochloride 8 mg (B group). The drugs in each group were diluted to 100ml. Analgesic pattern was background flow rate 2 ml/h with 0.5 ml self-controlled dose every time. Locking time was 15 min. The VAS score,pressing times and incidence of side effects were recorded during the period of postoperative 24 hours. Results: The VAS of group B at 8 h after operation was higher than that of group A (P<0.05),while the VAS of group B at 2,4,24 h were similar as group A (P>0.05). The accidence rate of nausea,vomiting in two groups were similar (P>0.05). The total accidence rate of group A was lower than that of group B (P<0.05). No respiratory depression or abnormal bleeding occurred in two groups. Conclusions: Intravenous postoperative analgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride has a better analgesic effect than tramadol hydrochloride alone and was a safe and effective therapy.