骨髓异常增生综合征骨髓涂片检查误诊分析

Analysis of misdiagnosis of myelodysplastic syndrome by bone marrow smears

摘要: 目的: 分析骨髓异常增生综合征(myelodysplastic syndrome,MDS)骨髓涂片检查误诊原因。方法: 对1992年2月~2003年12月我院误诊MDS47例骨髓涂片进行回顾性分析。结果: 难治性贫血误诊率最高达89.3%,主要误诊病种为增生性贫血、慢性再生障碍性贫血、巨幼红细胞性贫血、急性白血病等。结论: MDS诊断较为困难,应仔细结合病史、骨髓活检及细胞遗传学检查才能作出正确诊断。

Abstract: Objective: To analyze the causes of misdiagnosis of myelodysplastic syndrome(MDS) by bone marrow smears.Methods: Forty-seven patients with MDS misdiagnosed by bone marrow smears from February 1992 to December 2003 were analyzed retrospectively.Results: The misdiagnosis rate of refractory anemia(RA) reached 89.3%.The major misdiagnosed diseases were proliferous anemia(PA),chronic aplastic anemia(CAA),megaloblastic anemia(MA) and acute leukemia(AL).Conclusions: The diagnosis of MDS is relative difficult and correct diagnosis can be made by means of analysis of the patients' medical history,bone marrow biopsy and cytogenetics.