Abstract: Objective: To discuss the anesthesia effects of using sufentanil combined with propofol total intravenous anesthesia.Methods: Sixty patients with thoracic surgery were chosen and divided into two groups according to the random number method(30 cases in each group):the control group was given the traditional intravenous anesthesia;the observation group was given sufentanil 0.5~1.5 μg·kg^-1·h^-1 combined with propofol 3~5 mg·kg^-1·h^-1 venous continuous pump and 0.6 g·kg^-1·min^-1 of atracurium was used to keep muscle relaxan.The anesthesia effects and complications of the two groups were recorded and compared.Results: Heart rate of the two groups was declined at T1 compared with T0,and results showed that heart rate of the control group was higher than that of the observation group(P<0.01) from T2 to T5;systolic blood pressure(SBP) values of the control group were decreased at T1 compared with T0 while SBP values of the observation group were decreased at T3 compared with T0,and SBP values of the control group from T2 to T5 were higher than those of the observation group(P<0.01);at T4 SpO₂ values of the two group were higher than at T0,SpO₂ values of and the control group were higher than that of the observation group(P<0.01).In the control group the extubation time was(18.3±7.8) min,significantly longer than that in the observation group(12.8±6.9) min(P<0.01);Postoperative adverse reaction rate of the control group was 30.0% higher than that of the observation group 6.7%(P<0.05).Awakening period match rate in the observation group was 93.3% higher than that in the control group 80.0%(P<0.05).Conclusions: Using sufentanil combined with propofol has better anesthesia effects,also with shorter postoperative awake time and low incidence of adverse reactions,which is worthy of clinical promotion.