Abstract: Objective: To investigate the cognition and high-risk factors of diabetic foot in diabetic patients.Methods: The cognition and high-risk factors of diabetic foot in 120 patients with type 2 diabetes were investigated.Results: The cognitive rate of the related knowledge of diabetic foot and awareness rate of foot care and shoe selection of patients were 63.3% and 45.0%,respectively.The differences of the cognitive rate of the related knowledge of diabetic foot and awareness rate of foot care and shoe selection between patients with disease duration more than or equal to 10 years and less than 10 years were not statistically significant(P>0.05).The abnormal incidence of left leg ankle brachial index(21.7%) was higher than that of right lower limb(11.7%)(P<0.05).The risk incidence of vibration threshold in left and right lower limb were 26.7% and 16.7%,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: To improve the cognition and screen the high-risk factor of diabetic foot in diabetic patients can reduce the incidence of diabetic foot.