杨松保, 魏素云, 郑立东. 罗库溴铵预注在全身麻醉气管插管中的应用[J]. 蚌埠医学院学报, 2011, 36(3): 260-262.
    引用本文: 杨松保, 魏素云, 郑立东. 罗库溴铵预注在全身麻醉气管插管中的应用[J]. 蚌埠医学院学报, 2011, 36(3): 260-262.
    YANG Song-bao, WEI Su-yun, ZHENG Li-dong. Applications of rocuronium pretreatment in general anesthesia tracheal intubation[J]. Journal of Bengbu Medical College, 2011, 36(3): 260-262.
    Citation: YANG Song-bao, WEI Su-yun, ZHENG Li-dong. Applications of rocuronium pretreatment in general anesthesia tracheal intubation[J]. Journal of Bengbu Medical College, 2011, 36(3): 260-262.

    罗库溴铵预注在全身麻醉气管插管中的应用

    Applications of rocuronium pretreatment in general anesthesia tracheal intubation

    • 摘要: 目的: 观察罗库溴铵全身麻醉(全麻)诱导预注给药气管插管效果。方法: 48例ASAⅠ~Ⅱ级择期手术患者,随机分为罗库溴铵组(R组)24例和琥珀胆碱组(S组)24例,R组在全麻诱导前先静脉注射小剂量罗库溴铵0.06 mg/kg(1/5ED95),再静脉注射罗库溴铵0.6 mg/kg(2ED95),预注时间为1 min;S组诱导药同R组,最后静脉注射琥珀胆碱1.2 mg/kg(4ED95)。观察作用显效时间、起效时间、1 min T1值及T1最大抑制程度和平均动脉压(MAP)、心率(HR)、脉搏氧饱和度(SpO2)、呼气末二氧化碳分压(PETCO2)。结果: 2组插管条件评级组间差异无统计学意义(P>0.05),注药后T1最大抑制程度2组基本相似(P>0.05)。肌松药作用显效时间、起效时间和1 min T1值S组均比R组明显缩短(P<0.01)。MAP、HR、SpO2、PET CO2无明显变化(P>0.05)。结论: 预注罗库溴铵0.06 mg/kg(1/5ED95),时间1 min,插管时剂量0.6 mg/kg(2ED95)在全麻气管插管中是安全有效的。

       

      Abstract: Objective: To investigate the effects of rocuronium pretreatment in the patients of general anesthesia tracheal intubation. Methods: Forty-eight ASA Ⅰ-Ⅱ patients undergoing elective surgery under general anesthesia were randomly divided into two groups (24 cases/group):group rocuronium (group R) and group suxamethonium (group S). Intravenous pretreatment of rocuronium 0.06 mg/kg (1/5ED95) was given to group R while the equivalent volume of normal saline to group S. After induction of general anesthesia, rocuronium 0.6 mg/kg (2ED95) and suxamethonium 1.2 mg/kg (4ED95) were injected as a bolus to group R and group S,respectively. The effective time,the onset time,the T1 Value at one minute and the time of maximal depression of T1 were observed. At the same time,mean arterial pressure (MAP),heart rate (HR),hood oxygen satu ration (SpO2) and end tidal carbon dioxide (PET CO2) were observed respectively. Results: There were no significant differences in intubation conditions between the two groups (P>0.05); Furthermore,the largest extent of inhibition is general similar (P>0.05), while the effective time and onset time in group S was significant shorter than that in group R (P<0.01). There was no significant differences in MAP,HR,SpO2 and PETCO2. Conclusions: In our study,intravenous pretreatment of rocuronium 0.06 mg/kg (1/5ED95) plus 0.6 mg/kg intubation dose of rocuronium is effective and safety.

       

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