男性淋病患者奈瑟球菌57株药敏分析

肖航

男性淋病患者奈瑟球菌57株药敏分析

肖航

Sensitivity analysis of 57 strains of Neisseria gonorrhoeae isolated from male patients with gonorrhea

XIAO Hang

摘要

摘要: 目的:了解男性淋病患者奈瑟球菌对抗生素的药敏情况。方法:纸片扩散法检测57株淋病奈瑟球菌对7种抗生素的药敏。用头孢硝噻吩纸片法检测产青霉素酶淋病奈瑟菌(PPNG),以对四环素药敏纸片抑菌圈直径≤ 19 mm推测为高水平耐四环素淋病奈瑟球菌(TRNG)。结果:淋病奈瑟球菌对青霉素、四环素、环丙沙星敏感性分别为12.3%、17.5%、28.1%;对头孢噻肟、头孢他啶、头孢曲松耐药性分别为5.3%、3.5%、5.3%;无大观霉素耐药株。57株中检出14株PPNG菌株(24.6%),16株(28.1%)疑为TRNG。结论:淋病奈瑟球菌对青霉素、四环素、环丙沙星耐药性严重,这些药物已不再适合用于淋病治疗;第三代头孢菌素和大观霉素仍是一线用药,但应重视中介株,否则导致严重耐药性。

Abstract: Objective: To investigate the susceptibility of Neisseria gonorrhoeae strains isolated from male patients with gonorrhea to antibiotics.Methods: Disk diffusion method was used to test the sensitivity of 57 strains of Neisseria gonorrhoeae to 7 antibiotics.Pencillinase producing Neisseria gonorrhoeae(PPNG) was confirmed by nitrocefin disk.Results: The sensitivity rates of Neisseria gonorrhoeae to pencillin,tetracycline and ciprofloxacin was 12.3%,17.5% and 28.1%,respectively.The resistant rates of Neisseria gonorrhoeae to ceftizoxime,ceftazidime and ceftriaxone was 5.3%,3.5% and 5.3%,respectively.No strains were resistant to Spectinomycin.Of the 57 strains,14 were found to be PPNG(24.6%) and 16 were suspected to be TRNG(28.1%).Conclusions: Neisseria gonorrhea is highly resistant to pencillin,tetracycline and ciprofloxacin,so these drugs should be exclude for treatment of gonorrheae.Spectinomycin and the third generation cephalosporins may be selected as the first-line drugs in treating Neisseria gonorrhoeae.The strains between sensitivity and resistance should be noticed,in case that they will produce serious resistance.

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