Abstract: Objective: To analyze the related factors of nosocomial infection,the pathogen distribution and drug resistance in patients with lung cancer,so as to take effective measures and provide basis for rational use of drugs.Methods: The nosocomial infection in 328 cases of lung cancer patients were analyzed retrospectively.Results: Among the 328 cases of lung cancer,nosocomial infection occurred in 63 cases,and 96 times,with a rate of 19.21% (in cases) and 29.27% (in times),respectively;while it was 4.26% in other patients in the corresponding period of time.The infection mostly occurred in patients with lung cancer at the intermediate stage and the terminal stage.Severe malnutrition,complications and invasive operation were the predominant susceptibility factors.A total of 142 samples were submitted to detection,and pathogens were detected in 96 of them including 63 strains of G^- bacillus,24 strains of G⁺ cocci and 9 strains of fungi.The infection occurred mainly in the lower respiratory tract,and secondly in the digestive tract.Conclusions: There is a high incidence of nosocomial infection in patients with lung cancer.Susceptibility factors are varied.The main site of infection is the lower respiratory tract;the dominating pathogenic bacteria are G^- bacillus;bacterial resistance increases significantly.Rational use of antimicrobial agents may reduce the incidence of nosocomial infections and drug resistance.