多潘立酮、铝碳酸镁联用氟哌噻吨治疗慢性胃炎疗效观察
Combination therapy of flupenthixol,domperidone and hydrotalcite for chronic gastritis
-
摘要: 目的:探讨联用氟哌噻吨治疗慢性浅表性胃炎的疗效。方法:83例慢性浅表性胃炎(非萎缩)患者随机分为两组。对照组(41例)给予多潘立酮10mg,3次/天,铝碳酸镁1.0g,3次/天,疗程2周;治疗组(42例)在多潘立酮和铝碳酸镁治疗的基础上,加用氟哌噻吨,每天早晨和(或)中午口服,每次1mg,治疗2周。疗程结束后进行总疗效及单项疗效比较。结果:治疗组总有效率为92.9%,高于对照组的73.2%(P<0.05)。治疗组上腹胀、早饱、嗳气的缓解率均明显高于对照组(P<0.05)。而上腹痛和上腹不适缓解率两组差异均无统计学意义(P>0.05)。结论:在多潘立酮和铝碳酸镁治疗的基础上,联用氟哌噻吨能提高治疗慢性浅表性胃炎的疗效。Abstract: Objective: To investigate the effect of flupenthixol combined with domperidone and hydrotalcit on chronic superficial gastritis.Methods: Eighty-three patients with chronic superficial gastritis were randomized into two groups.The control group(41 cases) were given domperidone 10 mg and hydrotalcite 1.0 g 3 time per day for 2 weeks.The treatment group(42 cases) were given one pill of flupenthixol in the morning and/or at noon for two weeks.The total response rate and the effect on each symptom between the two groups were analyzed statistically.Results: The total response rate in the treatment group(92.9%) was higher than that in the control group(73.2%) (P<0.05).The remission rates of epigastric distention,early satiety and belching were higher in the treatment group than that in the control group(P<0.05).The remission rates of the upper abdominal pain or epigastric discomfort were not significantly different between the two groups(P>0.05).Conclusions: Flupenthixol combined with domperidone and hydrotalcite can improve the therapeutic effect on chronic superficial gastritis.