Abstract: Objective:To observe the effect of short-term insulin intensive therapy on the inflammation in newly-diagnosed type 2 diabetics.Methods:Twenty-one newly-diagnosed type 2 diabetic patients with fasting blood sugar(FBG)>11.1 mmol/L were treated by short-term insulin intensive therapy for 2 weeks.The fasting serum tumor necrosis factor-α(TNF-α) and CRP were compared before and after the therapy,and their relationship with △I30'/△G30',Homa-B function index and Homa-IR were observed.Results:After 2 weeks of treatment,the CRP,TNF-α and Hama-IR decreased significantly(P<0.01),and △I30'/△G30' increased significantly(P<0.05); Homa B was obviously increased (P<0.01);serum CRP and TNF-α was greatly related with Homa B function index and Hama-IR (P<0.05).Conclusions:Short-term intensive therapy may control the markedly increased blood glucose in newly-diagnosed type 2 diabetic patients and alleviate their inflammation reaction.