营养性肥胖大鼠模型的建立与血糖、血脂变化

Establishment of adult alimentary obese rats models and obsevation of the changes of glucose and lipid

摘要: 目的: 建立贴近临床的营养性肥胖大鼠模型,观察肥胖大鼠模型的形态与血糖、血脂变化情况。方法: 用高脂饲料喂养成年大鼠80天,观测大鼠体重、体长、Lee's指数及血糖、血脂水平。结果: 应用高脂饲料喂养后,大鼠体重、体长、Lee's指数与对照组差异均有统计学意义(P<0.001),大鼠的血糖、甘油三酯、总胆固醇和低密度脂蛋白均明显高于对照组(P<0.01~P<0.001),而高密度脂蛋白明显低于对照组(P<0.001)。结论: 高脂饲料可以使成年大鼠发生营养性肥胖,肥胖大鼠的血糖、血脂水平与对照组相比差异有统计学意义。

Abstract: Objective: To establish adult alimentary obese rats models and observe their changes in appearance, serum levels of glucose and lipid.Methods: The rats were fed with high fat food for 80 days and their weight, length and Lee's index were observed.Results: The weight, length and Lee's index had significant difference between the control group and the models (P<0.001).Fat rats had higher serum levels of glucose, triglyceride, total cholesterol and low-density lipoprotein, but lower high-density lipoprotein than normal rats (P<0.01-P<0.001).Conclusions: High fat food may cause alimentary obesity in adult rats, and there's significant difference in serum levels of glucose and lipid between the normal and obese rats.