2-(<i>E</i>)-取代苯亚甲基-5-二甲氨甲基环戊酮抗炎作用及胃肠道刺激性观察

2-(E)-取代苯亚甲基-5-二甲氨甲基环戊酮抗炎作用及胃肠道刺激性观察

摘要: 目的: 观察2-(E)-取代苯亚甲基-5-二甲氨甲基环戊酮(MB₄)的抗炎镇痛及对胃黏膜的刺激作用。方法: 对小鼠分别局部涂搽二甲苯致鼠耳肿胀,腹腔注射醋酸致扭体反应,灌胃给药致胃黏膜的刺激作用。结果: MB₄ 20mg/kg、40mg/kg对鼠耳肿胀度均有抑制作用(P<0.05和P<0.01),明显提高小鼠痛阈(P<0.01),但未见明显的胃刺激作用。结论: MB₄具有较好的抗炎镇痛作用,且对胃黏膜刺激性小。

Abstract: Objective: To observe the anti-inflammatory and analgesic activities of 2-(E)-(un)substituted benzylidene-5-dimethylamido-cyclopentanone(MB₄) and its irritating effect on gastrointestinal tract.Methods: Local besmear with xylene induced swelling of mice ear and the mice writhing caused by intraperitoneal injection acetic acid,the irritability of gastric mucous membrane by using intragastric administration.Results: MB₄(20mg/kg,40mg/kg) may inhibit the swelling of mice ear induced by xylene(P<0.05 and P<0.01),reduce writhing amount(P<0.01),but its irritating effect on gastrointestinal tract was slighter than that of indomethacin.Conclusions: MB₄ possess anti-inflammation and analgesic actions,but its irritative effects of gastric mucous membrane are small.