腺样体肥大患儿术后气流流场数值模拟及复发的危险因素分析

    Numerical simulation of postoperative airflow field in children with adenoid hypertrophy and analysis of risk factors of recurrence

    • 摘要:
      目的: 探讨腺样体肥大患儿术后气流流场的数值模拟及分析术后复发的危险因素。
      方法: 回顾性分析110例腺样体肥大患儿的临床资料并纳入训练集,选取同期于我院治疗的30例腺样体肥大患儿作为验证集。根据术后复发情况将训练集患儿分为复发组(22例)和未复发组(88例)。比较训练集和验证集患儿的临床资料、术前及术后的CT扫描和数值模拟结果,以及其他临床资料,使用多因素logistic回归分析患儿手术后出现复发的影响因素;构建列线图模型并评价模型效能。
      结果: 训练集患儿术前与术后的鼻咽腔容积、总体压强、气流流速分布差异有统计学意义(P < 0.05 ~ P < 0.01),与术前相比,患儿术后肥大腺样体的低密度影消失,后鼻孔及鼻咽部气道通畅,鼻窦黏膜基本恢复正常,鼻窦腔及和耳腔没有分泌物,可以清楚地见到咽鼓管咽口和咽隐窝。logistic多因素回归分析结果表明,术后感染、腺样体切除不完全、鼻(窦)炎、中耳炎、扁桃体炎是腺样体肥大患儿腺样体切除术后复发的危险因素(P < 0.05 ~ P < 0.01)。受试者工作特征(ROC)曲线以及校准曲线结果分析表示,列线图预测模型有着较高的区分度和准确度。
      结论: 术后感染、鼻(窦)炎、中耳炎等与腺样体肥大患儿术后复发相关,构建列线图模型(需要具体描述其预测结果)有利于临床制定个性化诊疗方案,以降低术后复发率。

       

      Abstract:
      Objective To explore the numerical simulation of the airflow field in children with adenoid hypertrophy after surgery, and analyze the risk factors for postoperative recurrence.
      Methods The clinical data of 110 children with adenoid hypertrophy were retrospectively analyzed, and included in the training set. Thirty children with adenoid hypertrophy who were treated in our hospital during the same period were selected as the validation set. According to the postoperative recurrence situation, the children in the training set were divided into the recurrence group (22 cases) and non-recurrence group (88 cases). The clinical data, preoperative and postoperative CT scans and numerical simulation results, as well as other clinical data between the training set and validation set were compared. Multivariate logistic regression was used to analyze the influencing factors of recurrence after surgery. A nomogram model was constructed, and the model's performance was evaluated.
      Results The differences of the nasopharyngeal cavity volume, overall pressure and airflow velocity distribution in the training set were statistically significant between before and after operation (P < 0.05 ~ P < 0.01). Compared with the operation, the low-density shadow of the hypertrophic adenoid disappeared after operation, the posterior nasal aperture and nasopharyngeal airway were unobstructed, the paranasal sinus mucosa basically returned to normal, and there were no secretions in the paranasal sinus cavity and ear cavity. The pharyngeal orifice and pharyngeal recess of the eustachian tube can be clearly seen. The results of logistic multivariate regression analysis showed that the postoperative infection, incomplete adenoidectomy, rhinosintis, otitis media and tonsillitis were the risk factors of recurrence after adenoidectomy in children with adenoid hypertrophy (P < 0.05 ~ P < 0.01). The analysis of the receiver operating characteristic (ROC) curve and calibration curve results indicated that the nomogram prediction model had a high degree of discrimination and accuracy.
      Conclusions Postoperative infections, rhinitis (sinusitis), otitis media, etc. are associated with the postoperative recurrence in children with adenoid hypertrophy. Constructing a nomogram model (which needs to specifically describe its predictive results) is conducive to the formulation of personalized diagnosis and treatment plans in clinical practice to reduce the postoperative recurrence rate.

       

    /

    返回文章
    返回