Abstract: Objective: To analyze the clinical effects of standard mega-bone flap craniotomy decompression in the treatment of severely craniocerebral injury.Methods: Seventy-eight patients with severely craniocerebral injury(Glasgow Coma Scale≤8 points) were treated with standard mega-bone flap craniotomy decompression.The Glasgow Outcome Scale and complications of all patients were observed in 6 months after treatment.Results: The delayed intracranial hematoma in 9 cases,cerebrospinal fluid leakage of incision in 2 cases,bilaterally subdural effusion in 5 cases,lung infection in 3 cases and epilepsy in 1 case were found after operation.All cases were followed up,good recovery in 16 cases,moderate disabilities in 17 cases,severe disabilities in 15 cases,vegetative state in 12 cases and death in 18 cases were verified.Five cases with secondary intracranial pressure were operated again.Conclusions: The standard mega-bone flap craniotomy decompression is an ideal surgical method in treating severely craniocerebral injury.The vital signs of patients after surgery should be closely observed,early detection and treatment of complications are important.