Abstract: Objective: To investigate the relationship between the expression of human papilloma virus (HPV)16/18 and the clinicopathologic parameters in cervical carcinoma. Methods: S-P immuno-histochemical method was used to detect the expression of HPV 16/18 in 42 patients with cervical carcinomas and 30 normal cervical tissues. The association between the expression of HPV 16/18 and the clinicopathologic parameters (such as age,histologic grade,clinical stage and lymph node metastasis) in cervical carcinomas was assessed. Results: The expression of HPV 16/18 in cervical carcinoma was significant higher than that in normal cervical tissues (P < 0.01). The expression of HPV 16/18 in lymph node was correlated with the clinical stage and lymph node metastasis of cervical carcinoma (P=0.032),but not related to the tumor histological grade or patients'age (P > 0.05 and P=1.000). Conclusions: The expression of HPV 16/18 is correlated with the clinicopathologic parameters and prognosis of cervical carcinoma,and may serve as a useful reference index to judge the lymph node metastasis of the cervical carcinoma.