T淋巴细胞亚群及mIPS评分在恶性血液病感染病人中的临床意义

洪娟; 褚先登; 丁美琪; 叶丽

T淋巴细胞亚群及mIPS评分在恶性血液病感染病人中的临床意义

The clinical significance of T lymphocyte subsets and mIPS scores in infection patients with malignant hematologic diseases

摘要

摘要:
目的： 探讨T淋巴细胞亚群及感染可能性评分（mIPS评分）在恶性血液病病人感染中的临床意义。
方法： 选取38例恶性血液病且行化疗治疗的成年病人作为研究对象，根据感染结局分为感染组21例和非感染组17例。比较2组mIPS评分、T淋巴细胞亚群、血常规及生化指标水平。
结果： 感染组病人mIPS评分、SOFA评分、C反应蛋白水平均明显高于非感染组（P ＜ 0.01）。感染组病人CD3⁺、CD4⁺、CD8⁺水平及中性粒细胞绝对值均低于非感染组（P ＜ 0.05 ~ P ＜ 0.01）。
结论： 早期检测T淋巴细胞亚群及进行mIPS评分，可对恶性血液病病人感染的发生起到提示及预测作用。

Abstract:
Objective To explore the clinical significance of T lymphocyte subsets and modified infection probability score (mIPS) in infection patients with malignant hematologic disease.
Methods A total of 38 adult malignant hematologic disease patients treated with chemotherapy were divided into the infection group (21 cases) and non-infectionb group (17 cases) according to their infection outcomes. The mIPS score, T lymphocyte subsets, blood routine and biochemical index levels were compared between two groups.
Results The mIPS score, SOFA score and C-reactive protein level in the infection group were significantly higher than those in non-infection group (P ＜ 0.01). The levels of CD3⁺, CD4⁺, CD8⁺ and neutrophils in the infection group were lower than those in non-infection group (P ＜ 0.05 ~ P ＜ 0.01).
Conclusions Early detection of T lymphocyte subsets and mIPS score can play a role in suggesting and predicting the occurrence of infection in patients with malignant hematologic diseases

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