Abstract: Objective: To discuss the X-ray manifestation and differential diagnosis of newborns with lung frequent hemorrhoid. Methods: The supine anteroposterior chest films of 60 neonates with lung frequent hemorrhoid were retrospectively analyzed. Among them,additional supine lateral chest film with horizontal projection was performed in 25 cases and spiral CT scanning in 4 cases. Results: The X-ray demonstrated that 38 cases had pneumothorax, 18 pneumomediastinum, 16 interstitial emphysema and 2 subcutaneous gas accumulation in the chest or the neck. No pneumatosis or pneumoperitoneum were detected. Two or more frequent hemorrhoidage performances were displayed in 20 cases; aspiration pneumonia was found in 52 cases; wet-lung disease was detected in 3 cases,1 of which was caused by high pressure of the breathing machine. Conclusions: X-ray photograph is most reliable in diagnosis of the neonate lung frequent hemorrhoid,and CT can help to confirm the location,scope and extent of the disease.