Abstract: Objective: To investigate the application of combined spinal and epidural anesthesia with 0.75% ropivacaine in lumbar disc hemiation operation.Methods: Forty patients receiving lumbar disc hemiation operation were randomly divided into two groups.Group A was administered 0.75% ropivacaine in addition to combined spinal and epidural anesthesia(CSEA),and group B was given only epidural anesthesia.The relative parameters concerning the circulation and respiration of the two groups during the operation were recorded and compared;at the same time,the intensity of pain and muscle relaxation were observed.Results: The evaluation of the intensity of pain and muscle relaxation in group A were significantly better than that in group B(P<0.01).No significant differences were found between group A and group B in blood pressure or heart rate(P>0.05).Conclusions: The combination therapy of 0.75% ropivation and CSEA is safe and effective for patients undergoing lumbar disc hemiation operation.