Abstract: Objective: To observe the complications incidence in patients received percutaneous coronary intervention(PCI) through radial artery and femoral artery puncture 24 hours after the operation. Methods: One hundred patients with coronary artery disease were divided into radial puncture group (group A, 43 cases) and femoral artery puncture group (group B, 57 cases). The complication incidence and side reaction 24 hours after PCI were compared between the two groups. Results: The incidence of local hematoma, wound bleeding, false aneurysm, vagal reflex and insomnia, limb and back pain in group A was significantly lower than that in group B; while the incidence of arterial spasm or occlusion in group A was higher than that in group B(P < 0.05-P < 0.01). Conclusions: Patients receiving PCI through the radial artery are less prone to complications and present a higher degree of comfort than those through the femoral artery puncture.