汪庚明, 江浩, 张磊, 项平, 承泽农. 肿瘤转移抑制基因KiSS-1在鼻咽癌中的表达及其意义[J]. 蚌埠医学院学报, 2009, 34(7): 579-581.
    引用本文: 汪庚明, 江浩, 张磊, 项平, 承泽农. 肿瘤转移抑制基因KiSS-1在鼻咽癌中的表达及其意义[J]. 蚌埠医学院学报, 2009, 34(7): 579-581.
    WANG Geng-ming, JIANG Hao, ZHANG Lei, XIANG Ping, CHENG Ze-nong. The expression of KiSS-1,a metastasis suppressor gene in nasopharyngeal carcinoma and its significance[J]. Journal of Bengbu Medical College, 2009, 34(7): 579-581.
    Citation: WANG Geng-ming, JIANG Hao, ZHANG Lei, XIANG Ping, CHENG Ze-nong. The expression of KiSS-1,a metastasis suppressor gene in nasopharyngeal carcinoma and its significance[J]. Journal of Bengbu Medical College, 2009, 34(7): 579-581.

    肿瘤转移抑制基因KiSS-1在鼻咽癌中的表达及其意义

    The expression of KiSS-1,a metastasis suppressor gene in nasopharyngeal carcinoma and its significance

    • 摘要: 目的:探讨KiSS-1在鼻咽癌组织中的表达及其临床意义。方法:应用逆转录聚合酶链反应(reverse transcription polymerase chain reaction,RT-PCR)检测31例鼻咽癌和14例非肿瘤性鼻咽部组织KiSS-1mRNA的表达情况,同时分析其与临床病理指标的关系。结果:KiSS-1mRNA在鼻咽癌组表达率为67.7%,非肿瘤性鼻咽部组为85.7%,两者差异无统计学意义(P>0.05),KiSS-1mRNA表达的高低与鼻咽癌患者的性别、年龄、病理类型和T分期等临床指标均无明显关系(P>0.05)。结论:KiSS-1在非肿瘤性鼻咽上皮高表达,在鼻咽癌中表达率降低。KiSS-1表达率降低与鼻咽癌的淋巴结转移有关,提示KiSS-1基因可能在鼻咽癌的转移中起重要作用。

       

      Abstract: Objective: To investigate the expression and clinical significance of KiSS-1 gene in nasopharyngeal carcinoma(NPC) tissue.Methods: KiSS-1 mRNA expression level was detected in 31 nasopharyngeal carcinoma tissues and 14 non-tumorous tissues by reverse transcription polymerase chain reaction(RT-PCR).The relationship between NPC and clinicopathological factors was also be analyzed.Results: The positive rate of KiSS-1 mRNA in nasopharyngeal carcinoma and non-tumorous nasopharyngeal tissues was 67.7% and 85.7%,respectively.The result was no significant difference between these two groups(P>0.05).No correlation was found between the expression of KiSS-1 gene and other clinicopathological factors such as patient's sex,age,T stage(P>0.05).Conclusions: KiSS-1 gene is highly expressed in non-tumorous nasopharyngeal tissue while low expressed in NPC.Loss of KiSS-1 expression was correlated with clinical stage and lymph node metastasis of NPC.These inclicated that KiSS-1 may play an important role in metastasis of NPC.

       

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