Abstract: Objective: To evaluate the efficacy of evidence-based nursing in health education of children with nephrotic syndrome.Methods: Sixty-eight children with nephrotic syndrome were randomly divided into evidence-based group and control group,with 34 cases in each.Evidence-based group were asked questions in accordance to the evidence-based steps;the literature was reviewed to find scientific evidence to formulate health education programs;the health education programs were implemented and evaluated.The control group were applied conventional health education programs.The rate of recurrence,the rate of reaching the standards of growth and development,and the satisfactory degree of the two groups were observed statistically.Results: The disease recurrence rate in the evidence-based group was significantly lower than that of the control group(P<0.01);the satisfactory degree in the evidence-based group was significantly higher than that in the control group(P<0.01);and there was significant difference between the two groups in the rate of growth and development of standards(P<0.05).Conclusions: Evidence-based method can be applied to health education of children with nephrotic syndrome,which may improve the patients' satisfaction degree,reduce the relapse rate of the disease and improve the life quality of the children.