Abstract: Objective: To study the efficacy and safety of 1-week triple therapy of omeprazole ilevofloxacin and furazolidone combined for Helicobacter pylori(Hp) eradication.Methods: One hundred patients with Hp infection suffering from chronic gastritis and peptic ulcer were randomized to treatment group and control group.The treatment group were administered omeprazole(20 mg,twice a day),levofloxacin(200 mg,twice a day) and furazolidone(100 mg,twice a day) for 1-week,while control group received omeprazole(20 mg,twice a day),clarithromycin(250 mg,twice a day) and metronidazole(400 mg,twice a day) for 1-week.The patients with peptic ulcer were treated with omeprazole(20 mg,every day) for another three weeks.Four weeks later,the Hp eradication,symptoms,peptic ulcer healing and side-effects were observed.Results: The Hp eradication rate,symptom ameliorate rate,peptic ulcer healing rate and side-effect rate between the treatment group and control group were 89.1% and 80.0%,93.5% and 88.9%,(92.5%) and 93.5%,21.74% and 24.44%,respectively.The difference was not significant(P>0.05).The cost of anti-Hp therapy of each patient was 107.82 Yuan(RMB) and 103.07 Yuan(RMB) in the treatment group and control group respectively.Conclusions: 1-week triple therapy of meprazole,levofloxacin and furazolidone combined is the first choice for Hp eradication.