Abstract: Objective: To explore the value of color doppler ultrasonography in diagnosis of breast cancer. Methods: One hundred and twenty-five patients with breast cancer were examined by doppler ultrasonography. The edge shape,internal echo,back echo,surrounding tissues and color doppler flow imaging were observed and analyzed. Results: One hundred and twenty cases were correctly diagnosed among 125 patients by postoperative pathology section. The diagnosis corresponding rate was 96.0%. The features of typical breast cancer included irregular profile,no obvious echo envelope,posteriorecho attenuation,grit calcification,and length and width diameter proportionality >1; but mastocarcinoma had no above features. Conclusions: Ultrasonic wave is of high value in diagnosis of breast cancer.