Objective To investigate the effect of Danhong injection combined with isokinetic muscle strength training on lower limb motor function and serum neuropeptide Y (NPY) and cyclic guanosine monophosphate (cAMP) in stroke patients with hemiplegia.

Methods A total of 100 stroke patients with hemiplegia were randomly divided into training group (50 cases) and combination group (50 cases). The training group was given isokinetic muscle strength training, and the combination group was given Danhong injection combined with isokinetic muscle strength training. The clinical efficacy, muscle strength level (flexor extensor peak torque ratio, flexor peak torque and extensor peak torque), lower limb motor function Holden walking function classification, Fugl Meyer Rating Scale (FMA), Berg Balance Scale (BBS), gait (gait speed, gait frequency, step length) and serum NPY, cAMP levels were compared between the two groups.

Results The total effective rate of the combined group was significantly higher than that of the training group (P ＜ 0.05). Compared with those before treatment, the peak torque ratio of flexor and extensor muscles, peak torque of flexor and extensor muscles, Holden walking function classification, FMA score, BBS score, gait speed, gait frequency, step length, and serum cAMP level were significantly increased in the two groups after treatment (P ＜ 0.05), and significantly increased in the combined group compared with the training group (P ＜ 0.05); Compared with that before treatment, the serum NPY of the two groups after treatment was significantly reduced (P ＜ 0.05), and compared with the training group, the combined group was significantly reduced (P ＜ 0.05).

Conclusion Danhong injection combined with isokinetic muscle strength training in the treatment of stroke hemiplegia can effectively improve lower limb motor function and muscle strength, improve gait, and regulate serum NPY and cAMP levels, with good effect.