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    多巴胺对低氧高碳酸诱发膈肌疲劳的治疗作用

    Effect of dopamine on diaphragmatic fatigue in vitro induced by hypoxic hypercapnic acidosis in rats

      摘要
    • 摘要: 目的: 观察多巴胺(dopamine,DA)对低氧高碳酸诱发膈肌疲劳的治疗作用。方法: 取SD大鼠32只,随机分为4组:对照组、对照+DA组、模型组及模型+DA组。对照组和对照+DA组通氧气(95% O2+5% CO2)作对照,其它两组通低氧高二氧化碳混合气(21% O2,12% CO2,67% N2)4 min复制膈肌疲劳模型,第2、4组各给DA (1 mmol/L),利用MedLab-U/4c生物信号采集处理系统采集数据,并分析单收缩力(Pt)、最大强直收缩张力(Po)、峰值收缩时间(CT)、半舒张时间(1/2RT)等。结果: 与对照组相比,模型组Pt、Po显著降低(P<0.05和P<0.01)。与模型组相比,治疗组Po显著升高(P<0.05)。予不同频率刺激膈肌时,模型组大鼠肌张力均低于对照组(P<0.05~P<0.01),而治疗组在高频刺激时肌张力明显高于模型组(P<0.05~P<0.01)。结论: DA能增强大鼠膈肌收缩功能,对低氧高碳酸所致膈肌疲劳具有治疗作用。

       

      Abstract: Objective: To observe the treatment effect of dopamine on diaphragmatic fatigue in vitro induced by hypoxic hypercapnic acidosis in rats.Methods: Thirty-two SD rats were divided into four groups at random:control group,control group with dopamine,model group,model group with dopamine.Control group and control group with dopamine were aerated oxygen(95%O2+5%CO2),model group and model group with dopamine were aerated hypoxic hypercapnic acidosis gas(21%O2,12%CO2,67%N2) for 4 min.At the same time dopamine (1 mmol/L) was added to the second and forth groups.Data(Pt,Po,CT,1/2RT) was recorded and analyzed using the Medlab-U/4c biological signal collecting system.Results: Compared with control group,the Pt,Po and contractile force under different frequency of model group decreased significantly(P<0.05 and P<0.01);but the Po and contractile force under the frequencies 30-100 Hz of dopamine increased significantly(P<0.05) compared with those of model group.Conclusions: Dopamine can improve contractility and treatment of high frequency fatigue induced by hypoxic hypercapnic acidosis to some extent.

       

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