Abstract: Objective: To analyze the polymorphism of ALOX5AP and PDE4D gene and molecular epidemiology of the susceptibility of cerebral infarction(CI).Methods: Three hundred and ninty-six patients with CI and 300 healthy people were divided into the CI group and control group.The polymorphism of SG13S89 and SG13S114 in ALOX5AP gene,and SNP83 in PDE4D gene in two groups were detected using PCR and matrix assisted laser desorption,and the relationship between the polymorphism of ALOX5AP and PDE4D gene and CI were analyzed.Results: The AG gene type and allele A frequency in SG13S89 in CI group were higher than those in control group(P< 0.05).Logistic regression analysis showed that the AG gene type in SG13S89 was the risk factor in increasing the CI after adjusting the influence factors of age,hypertension and diabetes mellitus(P< 0.05).The differences of the gene type and frequency of AT and SAD in SG13S89 gene of cerebral infarction patients were not statistically significant(P>0.05).The age stratification analysis found that female was the risk factor of the CI in increasing AG gene type of SG13S89 of patients(P< 0.05).Conclusions: The frequency of CI in the patients with AG type and A allele in SG13S89 is higher than other alleles,the possible mechanism of which is implemented through mediating vascular inflammatory reaction,and the relationship between the polymorphism of SG13S114 and SNP83 gene and CI is not found.