血清TSGF、CEA、CA242、CA19-9联合检测对消化道恶性肿瘤的诊断价值

徐伟刚; 胡梅齐; 陆群

血清TSGF、CEA、CA242、CA19-9联合检测对消化道恶性肿瘤的诊断价值

Combined detection of serum TSGF, CEA, CA242 and CA19-9 in diagnosis of malignant tumors of digestive tract

摘要

摘要: 目的: 探讨恶性肿瘤特异性生长因子(T SG F)、癌胚抗原(CEA)、糖抗原242(CA242)、糖抗原19-9(CA19-9)联合检测对消化道恶性肿瘤的诊断价值。方法: 采用生化或放免分析法检测236例消化道恶性肿瘤患者血清T SGF、CEA、CA 242、CA19-9含量,与对照组比较,并分析结果。结果: 以单一指标阳性作为诊断标准,TSGF、CEA、CA242、CA19-9对消化道恶性肿瘤的灵敏度分别为79.24%、31.78%、42.80%、55.51%;特异度分别为82.76%、97.84%、98.71%、92.24%;准确度分别为80.98%、64.53%、70.51%、73.72%。联合检测的灵敏度为90.25%,特异度为72.41%,准确度为81.41%。结论: 血清TSGF、CEA、CA242、CA19-9联合检测对消化道恶性肿瘤的辅助诊断有较高的临床应用价值。

Abstract: Objective: To explore the diagnostic value of serum tumor specific growth factor(TSGF),carcinoembryonic antigen(CEA),CA242 and CA19-9 combined in detecting malignant tumors of digestive tract.Methods: The levels of serum TSGF,CEA,CA242 and CA19-9 were determined by biochemical or immunoradiometric assay in patients with malignant tumors of digestive tract and in control group.Results: The sensitivity rates of using single positive diagnostic indicator of TSGF,CEA,CA242 and CA19-9 to malignant tumors of digestive tract were 79.24%,31.78%,42.80% and 55.51%,respectively.The specific rates were 82.76%,97.84%,98.71% and 92.24%,respectively.The accuracy rates were 80.98%,64.53%,70.51% and 73.72%,respectively.In combined detection,the diagnostic sensitivity rate was 90.25%,the specific rate was 72.41%,and the accuracy rate was 81.41%.Conclusions: Detecting serum TSGF,CEA,CA242 and CA19-9 combinedly is of great clinical value for the diagnosis of malignant tumors of digestive tract.

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