Abstract: Objective: To compare the effects of three analgesia methods on the hemodynamic of hypertensive patients receiving the lower limb bone surgery.Methods: Forty-five hypertensive patients with ASA,Ⅱ-Ⅲ undergoing lower limb bone surgery were randomly divided into 3 groups(n=15).Epidural analgesia group(group E)were administered loading dose of morphine 2 mg,morphine 0.08 mg/kg+0.75% bupivacaine 150 mg+droperidol 2 mg;intravenous analgesia group(group I)received loading dose of tramadol 100 mg,fentanyl 0.012 mg/kg+tramadol 400 mg+droperidol 2 mg;Pethidine analgesia group(group D)were given intramuscular injection of pethidine 100 mg when necessary.The visual analogue scales,adverse effects,and SBP,DBP,HR,etc.were recorded at the time point of 0,1,4,8,12,24 and 48 hour after operation.Results: Group E and I didn't show any significant difference in the analgesic effects(P>0.05).The hemodynamic response of group E was the most stable in the 3 groups and the second was group I;the hemodynamic response of group D wasn't stable(P<0.01).Conclusions: For the hypertensive patients receiving lower limb bone surgery,PCEA is safe and effective,and ND can keep the stability of their hemodynamic responses.