Abstract: Objective: To study the therapeutic effect of Yiqihuoxue decoction on treatment of carotid arteriosclerosis plaque.Methods: Fifty-eight patients with carotid arteriosclerosis plaque were randomly divided into two groups,these cases in control group were given routine depressurization,decreasing the concentration of glucose and anti-platelet aggregation treatments,while Yiqihuoxue decoction was taken orally twice a day for these cases who belong to treatment group,200 ml every time.The carotid artery diameter,thickness of intima media,plaque size and the changes of haemorheology were recorded after 8 weeks.Results: Compared with pre-treatment,the changes of haemorheology were obviously improved in treatment group,intima media in carotid artery was obviously thinner.Plaque in carotid angiosclerosis was smaller or even disapeared.There was a statistical significance of efficiency variance in contrast to the control group(P<0.01).Conclusions: Yiqihuoxue decoction can play an effective role on treatment of carotid arteriosclerosis plaque.