Abstract: Objective:To observe the effect of perflutren(C₃F₈) injection and cryosurgery using binocular indirect ophthalmoscope in treatment of rhegmatogenous retinal detachment(RRD) with giant retinal tears.Methods:Twenty-three patients (24 eyes) with RRD received cryosurgery under the binocular indirect ophthalmoscope,and C₃F₈ was injected into the vitreous cavity;scleral compressing,scleral buckling and subretinal fluid releasing were performed accordingly.Results:Twenty-one eyes had retinal reattachment after one operation,two eyes had retinal reattachment after twice operation,and one eye was performed vitrectomy.Conclusions:C₃F₈ injection in the vitreous cavity combined with cryosurgery using binocular indirect ophthalmoscope are safe and effective for treatment of rhegmatogenous retinal detachment with giant retinal tears.