Abstract:
Objective: To study the effect of different target concentrations of sufentanil on the stress response to the hypertension patients tracheal intubation during induction of general anesthesia.
Methods: Sixty hypertension patients were randomly divided into three groups with 20 cases each. Each group received a sufentanil target concentration(STC) of 0.2 ng/ml(S1),0.4 ng/ml(S2) and 0.6 ng/ml(S3),respectively. Mean arterial pressure(MAP),heart rate(HR),and bispectral index(BIS) were recorded at the time points of record baseline(T
0),immediately before intubation(T
1),immediately after intubation(T
2),1 min after intubation(T
3),3 min after intubation(T
4).
Results: Compared to T
0 point,Map and HR of S2 and S3 were decreased(
P < 0.05-
P < 0.01); MAP and HR of S2 were all significant increased at T
2,T
3,T
4 point(
P < 0.01), and of S3 at T
3,T
4 were signicantly decreased. Compared with T
0 point,BIS value of three groups were all decresed(
P < 0.01),in which were in 45-55 range at T
1,T
2,T
3,T
4 of S2. BIS value of S1 were higher than 55 and of S3 were lower than 45,indicating too shallow or deep anesthesia. Comparison of norepinephrine (NE) concentration:T
0 compared,S1,S2,S3 at each time point was no significant difference(
P > 0.05). Comparison with epinephrine(E) concentration:compared with T
0,T
3 of S1 was higher(
P < 0.05). T
3,T
4 of S3 were always lower than S1(
P < 0.05-
P < 0.01),the difference was statistically significant.
Conclusions: The hemodynamic response to the hypertension patients during induction of general anesthesia is stable as the target concentration of 0.4 ng/ml.