慢性乙型肝炎重叠戊型肝炎感染40例临床分析

汪传富; 姜春林

慢性乙型肝炎重叠戊型肝炎感染40例临床分析

Clinical analysis of chronic hepatitis B patients with hepatitis E super-infection:a report of 40 cases

摘要

摘要: 目的: 观察慢性乙型肝炎患者重叠戊型肝炎病毒感染的临床特点及戊型肝炎病毒对慢性乙型肝炎患者的影响。方法: 对40例慢性乙型肝炎病毒重叠戊型肝炎病毒感染组患者与40例单纯慢性乙型肝炎病毒感染组患者的临床特点进行对照分析。结果: 2组总胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、凝血酶原活动度、血白蛋白差异均有统计学意义(P<0.05~P<0.01);重叠感染组HBeAg阴转率、HBV-DNA阳性率低于对照组(P<0.05)。结论: 慢性乙型肝炎病毒感染者重叠戊型肝炎病毒感染可使病情急性加重并形成重症化,但戊型肝炎病毒对乙型肝炎病毒复制有一定的抑制作用。

Abstract: Objective: To observe the clinical characteristics of chronic hepatitis B patients with hepatitis E overlap-infection,and the influence of hepatitis E virus on patients with chronic hepatitis B.Methods: The clinical features of 40 patients with chronic hepatitis B overlapped with hepatitis E super infection and 40 patients with pure chronic hepatitis B infection were analyzed and compared.Results: The total bilirubin,alanin amino transferase,the aspartic acid amino transferase,the zymoplasm original activity and the blood albumin of the two groups differed significantly (P<0.05-P<0.01);the negative rate of HBeAg and the positive rate of HBV-DNA of the super infection group were lower than those of the control group (P<0.05).Conclusions: The chronic hepatitis B patients with hepatitis E overlap infection may resulted in acute aggravation and critical illness,but hepatitis E virus has certain inhibitory effect on the duplication of hepatitis B virus.

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