子宫颈癌淋巴结中人乳头瘤病毒检测的临床意义

Detection of human papillomavirus in the lymph node of cervical carcinoma and its clinical significance

摘要: 目的:检测宫颈癌淋巴结中人乳头瘤病毒(HPV)的表达,探讨HPV表达与宫颈癌的临床病理参数之间的关系。方法:用免疫组织化学(S-P法)技术检测42例子宫颈鳞癌淋巴结中HPV表达,结合患者的临床病理参数进行分析。结果:淋巴结HPV阳性与子宫颈癌临床分期和淋巴结转移有一定关系(P=0.029和P<0.05),而与发病年龄无明显关系(P=1.000)。结论:淋巴结HPV检测可作为预测子宫颈癌淋巴转移和判断预后的一项参考指标。

Abstract: Objective: To detect the expression of human papillomavirus(HPV) in the lymph node of cervical carcinoma,and to investigate the relationship between the expression of HPV in the lymph node and clinicopathologic parameters of cervical carcinoma.Methods: The expression of HPV in the lymph node of 42 cases of squamous cervical carcinoma was analyzed retrospectively by S-P immunohistochemical method.The association between HPV expression and clinicopathologic parameters of the cervical carcinoma was assessed.Results: The exression of HPV in the lymph node was correlated with the clinical stage and lymph node metastasis of cervical carcinoma(P=0.029 and P<0.05),but was not related to the age of patients(P=1.000).Conclusions: Expression of HPV in lymph node may act as a usefu1 reference index in predicting lymphatic metastasis and prognosis of cervical carcinoma.