Abstract: Objective: To observe the effect of L-carnitine supplementation on lipid parameters and albumin of patients with hemodialysis.Methods: Thirty-four regularly dialyzed patients were randomly divided into treatment group and control group.The patients in the treatment group were given 1.0 g L-carnitine intravenously two times per week(after each hemodialysis session) for 3 months and the controls were not.The laboratory markers of lipid metabolism and albumin were measured before the supplementation and 3 months after the treatment.Results: The albumin concentration and serum triglycerides increased significantly in the treatment group(P<0.05).Conclusions: Regular carnitine supplementation can reduce the serum levels of TG and increase the albumin of hemodialysis patients.