李卫, 李铭, 李永华, 李丽军. 人工肝血浆置换治疗慢性重型乙型肝炎20例临床分析[J]. 蚌埠医学院学报, 2010, 35(4): 385-387.
    引用本文: 李卫, 李铭, 李永华, 李丽军. 人工肝血浆置换治疗慢性重型乙型肝炎20例临床分析[J]. 蚌埠医学院学报, 2010, 35(4): 385-387.
    LI Wei, LI Ming, LI Yong-hua, LI Li-jun. Artificial liver plasma exchange for treatment of chronic severe hepatitis B:a report of 20 cases[J]. Journal of Bengbu Medical College, 2010, 35(4): 385-387.
    Citation: LI Wei, LI Ming, LI Yong-hua, LI Li-jun. Artificial liver plasma exchange for treatment of chronic severe hepatitis B:a report of 20 cases[J]. Journal of Bengbu Medical College, 2010, 35(4): 385-387.

    人工肝血浆置换治疗慢性重型乙型肝炎20例临床分析

    Artificial liver plasma exchange for treatment of chronic severe hepatitis B:a report of 20 cases

    • 摘要: 目的:观察人工肝血浆置换治疗慢性重型乙型肝炎的临床效果及安全性。方法:将40例慢性重型乙型肝炎患者随机均分为治疗组与对照组。2组患者入院后均给予相同的内科综合治疗,治疗组加用人工肝血浆置换治疗。比较两组治疗前后临床表现、主要实验室指标及人工肝血浆置换治疗不良反应。随访3~12个月的存活率判断近期和远期疗效。结果:治疗组血浆置换后临床症状有明显好转,ALT、AST、总胆红素、肌酐均明显降低(P<0.01),凝血酶原活动度显著升高(P<0.01);40例次治疗中仅有3例次出现不良反应,总发生率为7.5%;治疗组总存活率为70.0%,高于对照组的35.0%(P<0.05)。结论:人工肝血浆置换术是慢性重型乙型肝炎安全、有效的治疗手段。

       

      Abstract: Objective: To observe the efficacy and safety of artificial liver plasma exchange in treatment of chronic severe hepatitis B.Methods: Forty cases of chronic severe hepatitis B were randomly divided into treatment group and control group.Both groups were given comprehensive medical treatment,and the patients in treatment group were administered liver plasma exchange therapy.The clinical manifestation before and after treatment,the main laboratory indicators and the adverse reactions of the patients receiving liver plasma exchange therapy were compared.The short and long term effects were evaluated according to the survival rate during the 3-12 months' follow-up.Results: The symptoms of the 20 cases receiving liver plasma exchange therapy improved significantly;alanine aminotransferase,aspartate aminotransferase,total bilirubin and creatinine decreased (P<0.01),and prothrombin activity increased (P<0.01);only 3 of the 40 cases presented adverse reactions (7.5%);the survival rate was 70.0%,which was higher than that of 35.0% in the control group (P<0.05).Conclusions: Artificial liver plasma exchange is safe and effective for treatment of chronic severe hepatitis B.

       

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