Abstract: Objective: To evaluate the efficacy of testosterone undecanoate combined with tadalafil(TUT) in the treatment of type 2 diabetic erectile dysfunction(DED) for providing a new treatment way.Methods: One hundred and fifteen patients with DED were treated with TUT for 3 months.The score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level in all patients before and after treatment were compared.Results: Compared with before treatment,the score of International Index of Erectile Function-5,sexual intercourse success rate and serum testosterone level of patients were obviously improved after treatment(P<0.01).Conclusions: TUT therapy is safe,effective and less adverse reaction,which can significantly improve the quality of sex life of patients,and is worthy of promotion.