Abstract: Objective:To discuss the clinical features,pathophysiology and treatment of diabetic ketoacidosis(DKA). Methods:All of 50 patients were treated with reasonable fluid infusion,small doses of insulin, improving electrolyte disturbances,and eliminating the inducing factors. Results:The level of blood glucose decreased and hyperlipoidemia was improved in 24 hours and the potassium, sodium and chlorine became normal in 48 hours in all of the patients with treatment. Carban dioxide-combining power was rised to normal in 2 to 3 days and the ketonebody was negative in 3 to 5 days in 40 patients. There were ten critical patients in all of the 50 patients. Carban dioxide-combining power became normal in one week and ketonebody was negative in 7 to 10 days in the 10 critical patients. Conclusions:Diabetic ketoacidosis was in rapidly progress and acucte onset. The key treatment to a successful rescue is enough fluid infusion at the very beginning stage and with timely diagosis.