甘草酸二胺注射液治疗化疗所致药物性肝损害临床疗效观察

    Ganlixin injection solution in treatment of hepatic-lesion caused by chemotheraphy

    • 摘要: 目的: 观察甘草酸二胺注射液治疗化疗所致药物性肝损害的效果。方法: 化疗后出现药物性肝损害的患者88例随机分为两组,甘草酸二胺组45例,给予甘草酸二胺30ml加入10%葡萄糖注射液250ml中静脉滴注,每天1次;甘草酸单胺组43例给予甘草酸单胺60ml加入10%葡萄糖注射液250ml中静脉滴注,每天1次;分别在治疗5天和10天后进行疗效评定,对治疗前后肝功能指标丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(γ-GT)进行对比分析。结果: 治疗后5天甘草酸二胺组有效率55.56%,甘草酸单胺组30.23%(P<0.05),治疗后10天甘草酸二胺组有效率88.89%,甘草酸单胺组55.81%(P<0.01),各项肝功指标对比提示甘草酸二胺的降酶作用显著。结论: 甘草酸二胺注射液治疗化疗后所致药物性肝损害经济安全有效。

       

      Abstract: Objective: To observe the effect of ganlixin in treating hepatic-lesion caused by chemotheraphy.Methods: Eighty-eight patients with hepatic-lesion related to chemotherathy were randomly divided into two groups.Forty-five cases were administrated ganlixin at a dose of 30 ml/d with 10 percent of 250 ml glucose solution by injection,and 43 cases received qianglilin at a dose of 60 mg/d with 10 percent of 250 ml glucose solution by injection.The effect was evaluated with hepatic function marker,such as AST,ALT and r-GT 10 days after treatment.Results: The recovery rate of ganlixin group was 88.89%,while the recovery rate of qianglilin group was (55.81%)(P<0.01).Conclusions: The result indicates that ganlixin is more effective than qianglilin in treatment of hepatic-lesion.

       

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