Abstract: Objective:To analyze the therapeutic effects of total glucosides of paeony(TGP) for ankylosing spondylitis(AS).Methods:By literature analysis based on evidence-based medicine,randomized controlled trials about TGP in the treatment of AS were obtained from Chine National Knowledge infrastructure,VIP and PubMed.Evaluated the quality of included studies and extracted the data.Rev Man 5.0 software was used for Meta analysis.Results:Eleven randomized controlled trials with a total of 692 patients were included.Results of meta-analysis showed that the total effective rate of TGP group was higher than that of control group,and the difference was statistically significantOR=3.36,95%CI(2.03,5.54),P<0.01.As to the adverse reaction,the TGP group has a rather lower incidence than that of control group,and the difference was statistically significantOR=0.34,95%CI(0.21,0.53),P<0.01.At the same time,statistical significances were found in reducing C-reactive protein and Bath ankylosing spondylitis disease activity index between these two groups,result of Meta-analysis isMD=-6.07,95%CI(-9.44,-2.70),P<0.01 andMD=-2.66,95%CI(-5.16,-0.15),P<0.05 respectively.No statistically difference was found in reducing erythrocyte sedimentation rate and Bath ankylosing spondylitis functional index between these two groups,result of Meta-analysis isMD=-2.20,95%CI(-9.52,5.12),P>0.05 andMD=-7.50,95%CI(-21.31,6.31),P>0.05 respectively.Conclusions:TGP can improve clinical efficient and reduce adverse reaction significantly.