Abstract: Objective: To investigate the anti-aging effect and mechanism of dendrobium huoshenese capsule on drosophila.Methods: Newly trapped and not matea drosophila melangnogaster were collected within 8 hours,the drosophilas were cultured for 20 days in medium,and were randomly divided into 4 groups,each cultured with 0.000%,0.056%,0.167% and 0.500% concentrations of dendrobium huoshenese capsule.The drosophila's life span was detected with survival test.When the drosophilas were given varied concentrations of Dendrobium Huoshenese capsule for 10,20,30 days,superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were measured respectively.Results: When the drosophilas were treated with 0.056%,0.167%,0.500% concentrations of dendrobium huoshenese capsule,the half died time,maximum average life span and average life span were prolonged significantly (P<0.01),and SOD activity was increased remarkably (P<0.05) while MDA content was decreased (P<0.05) in the drosophila given the middle and high concentrations of dendrobium huoshenese capsule for 10,20,30 days.Conclusions: Dendrobium Huoshenese capsule has the anti-oxidation and anti-aging effects on drosophila.