Abstract: Objective: To survey the grateful disposition in college students and to analyze the related factors. Methods: One thousand three hundreds college students in four colleges in one city were investigated with a self-designed questionnaire including sociology of population data and Gratitude Questionnaire 6. Results: The scores were significantly different in students of different gender, birthplaces,whether or not being the only child in the family,and students in the medical college and other colleges (P < 0.01); no significant difference was observed in the students having or having not accepted aids (P > 0.05). The grateful disposition was related to the gender,number of children in the family,mother's education level and family income (P < 0.05 to P < 0.01),but not to father's education level (P > 0.05). Conclusions: The grateful disposition of the college students is influenced by the family,school and society.