Objective To explore the clinical effect of uterine artery blocking combined with uterine fibroidectomy and its impact on the function of ovarian reserve.

Method From January 2021 to January 2024, 102 patients diagnosed with uterine fibroids at the Anhui Medical University-affiliated Lu'an Hospital were randomly assigned to either the control group or the observation group, 51 cases each. The control group underwent laparoscopic myomectomy, while the observation group underwent uterine artery occlusion combined with myomectomy. The surgical indicators, interleukin-1 (IL-1), interleukin-6 (IL-6), serum tumor necrosis factor α(TNF-α), serum luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E₂), the number of antral follicles, and the incidence of complications were observed in the two groups.

Results The observation group had lower intraoperative blood loss than the control group (P ＜ 0.05); the postoperative 3d study group IL-1, IL-6 and TNF-α were lower than that of the control group (P ＜ 0.05); there was no statistical difference in the number of LH, FSH, E₂ and sinus follicles in the two groups before, 1 month after surgery and 3 months after surgery (P ＞ 0.05); and there was no statistical difference in the incidence of in the incidence of incision infection, pelvic infection, poor incision healing and abnormal menstruation between the two groups (P ＞ 0.05).

Conclusion Uterine artery blocking combined with hysteromyoma resection can reduce the amount of intraoperative bleeding and reduce inflammatory reactions, have little impact on hormone levels and ovarian reserve function, lower incidence of postoperative complications, and high clinical promotion and application value.