产超广谱β-内酰胺酶大肠埃希菌耐药性分析

Analysis of antibiotic resistance of extended-spectrum β-lactamases-producing Escherichia coli strains

摘要: 目的:了解产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的耐药性,为临床合理选用抗生素提供依据。方法:2005年9月~2006年6月,收集临床分离产ESBLs大肠埃希菌63株,采用琼脂平皿稀释法进行MIC测定。结果:产ESBLs大肠埃希菌对碳青霉烯类和哌拉西林/他唑巴坦普遍敏感,对哌拉西林和喹诺酮类耐药率分别为98.41%和90.48%,对头孢吡肟、头孢哌酮/舒巴坦、头孢他啶、头孢西丁、头孢噻肟和头孢曲松耐药率依次为34.92%、36.51%、44.45%、55.56%、82.54%和84.13%。结论:我院产ESBLs大肠埃希菌耐药明显。

Abstract: Objective: To study the resistance of the extended-spectrum β-lactamases(ESBLs) -producing Escherichia coli(E.coli) strains and to provide basis for clinical therapy.Methods: Agar dilution method was used to determine MICs of 13 antibiotics against 63 strains of ESBLs-producing E.coli which were collected between October 2005 and June 2006 in our hospital.Results: ESBLs-producing E.coli was generally sensitive to carbopenems and piperacillin/tazobatan,while most strains were highly resistant to piperacillin and quinolones.The rate of resistance to cefepime,ceforazone/sulbactam,ceftazidime,cefoxitin,ceftaxime and ceftriaxone were 34.92%,36.51%,44.45%,55.56%,82.54% and 84.13%,respectively.Conclusions: ESBLs-producing E.coli strains are highly resistant to antibiotics in our hospital.